People still remember the outbreak of bird flu in the world in 2005. Star anise, a traditional Chinese spice, is gradually valued by people because it contains Tamiflu-shikimic acid, the raw material of anti-avian flu medicine, because it is a pure natural extraction. Free of hormones and prohibited ingredients, and no side effects to health, star anise extract-shikimic acid is being widely used in various fields and industries.
Shikimic acid can directly affect the metabolism of arachidonic acid, inhibit platelet aggregation, inhibit arterial and venous thrombosis and prothrombosis. Shikimic acid also has anti-inflammatory and analgesic effects. Shikimic acid can be used as an intermediate of antiviral and anticancer drugs, and can also be converted into a variety of substances that have inhibitory and killing effects on viruses, bacteria and cancer cells in vivo.
Antibacterial and antiviral effects of shikimic acid: In 1987, it was reported that Japanese scholars found that a compound of shikimic acid had a significant inhibitory effect on HeLacells and Ehrlichascitescarcinoma, and could prolong inoculation. The survival time of mice with leukemia cells L121O is relatively low, and its inhibitory effect is mainly related to the hydrosulfide reaction. After the influenza virus is replicated, expressed and assembled in the host cell, it will protrude from the host cell in the form of budding, but it is connected to the host cell with thrombin-sialic acid. Neuraminidase uses sialic acid as a substrate, which can catalyze sialic acid. Hydrolysis removes the link between the mature virus particle and the host cell, allowing it to move freely and invade other healthy host cells. For example, inhibiting the activity of neuraminidase can prevent the release of virus particles and cut off the diffusion chain of the virus, thereby inhibiting the replication of the virus. When used within 24 hours after the onset of the disease, the course of the disease will be shortened by 20 percent to 30 percent , and the disease will be reduced by 25 percent . As a preventive drug, the protection rate of influenza virus exposure is between 60 percent and 80 percent . In addition, the antiviral effect can be achieved by blocking the synthesis of the glycoprotein of the virus and inhibiting the release of the virus from the cell after maturation. After oral administration, it is rapidly absorbed and enters the blood circulation, and reaches the peak plasma concentration after 2 to 3 hours.
While shikimic acid exerts its efficacy in vivo, its derivative products in vivo also have antiviral effects, so the efficacy is stable for a longer time. The mode of action is unique: it directly inhibits the release of virus particles from cells, thereby preventing them from further infecting normal cells, and plays a role in rapidly controlling the disease. It has a strong inhibitory effect on various DNA and RNA viral diseases, especially for H5N. No incompatibility: this product has no incompatibility with other antibacterial and antiviral drugs, and the unique detection method of this product has no cross detection with other drugs. Therefore, it does not affect the legality of product testing.
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